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Structural-function Discovery Laboratory

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Publications

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Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine

Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine
  • AuthorHuijeong Ryu, Tyler L. Grove, Steven C. Almo, and Jungwook Kim
  • Year2018
  • SourceNucleic Acids Research. 2018 Sep 28;46(17):9160-9169. doi: 10.1093/nar/gky592

Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification
  • AuthorJungwook Kim, Hui Xiao, Junseock Koh, Yikai Wang, Jeffrey B. Bonanno, Keisha Thomas, Patricia C. Babbitt, Shoshana Brown, Young-Sam Lee, and Steven C. Almo
  • Year2015
  • SourceNucleic Acids Res. 2015 May 19;43(9):4602-13. doi: 10.1093/nar/gkv206

Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes
  • AuthorMatthew W. Vetting, Nawar Al-Obaidi, Suwen Zhao, Brian San Francisco, Jungwook Kim, Daniel J. Wichelecki, Jason T. Bouvier, Jose O. Solbiati, Hoan Vu, Xinshuai Zhang, Dmitry A. Rodionov, James D. Love, Brandan S. Hillerich, Ronald D. Seidel, Ronald J. Quinn, Andrei L. Osterman, John E. Cronan, Matthew P. Jacobson, John A. Gerlt, and Steven C. Almo
  • Year2015
  • SourceBiochemistry. 2015 Jan 27;54(3):909-31. doi: 10.1021/bi501388y

Large-scale determination of sequence, structure, and function relationships in cytosolic glutathione transferases across the biosphere
  • AuthorSusan T. Mashiyama, M. Merced Malabanan, Eyal Akiva, Rahul Bhosle, Megan C. Branch, Brandan Hillerich, Kevin Jagessar, Jungwook Kim, Yury Patskovsky, Ronald D. Seidel, Mark Stead, Rafael Toro, Matthew W. Vetting, Steven C. Almo, Richard N. Armstrong, and Patricia C. Babbitt
  • Year2014
  • SourcePLoS Biol. 2014 Apr 22;12(4):e1001843. doi: 10.1371/journal.pbio.1001843

Global structures of IgG isotypes expressing identical variable regions
  • AuthorErtan Eryilmaz, Alena Janda, Jungwook Kim, Radames J. B. Cordero, David Cowburn, and Arturo Casadevall
  • Year2013
  • SourceMol Immunol. 2013 Dec;56(4):588-98. doi: 10.1016/j.molimm.2013.06.006

Structure-guided discovery of new deaminase enzymes
  • AuthorDaniel S. Hitchcock, Hao Fan, Jungwook Kim, Matthew Vetting, Brandan Hillerich, Ronald D. Seidel, Steven C. Almo, Brian K. Shoichet, Andrej Sali, and Frank M. Raushel
  • Year2013
  • SourceJ Am Chem Soc. 2013 Sep 18;135(37):13927-33. doi: 10.1021/ja4066078

Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function
  • AuthorJungwook Kim, Hui Xiao, Jeffrey B. Bonanno, Chakrapani Kalyanaraman, Shoshana Brown, Xiangying Tang, Nawar F. Al-Obaidi, Yury Patskovsky, Patricia C. Babbitt, Matthew P. Jacobson, Young-Sam Lee, and Steven C. Almo
  • Year2013
  • SourceNature. 2013 Jun 6;498(7452):123-6. doi: 10.1038/nature12180

Testing the sulfotransferase molecular pore hypothesis
  • AuthorIan Cook, Ting Wang, Steven C. Almo, Jungwook Kim, Charles N. Falany, and Thomas S. Leyh
  • Year2013
  • SourceJ Biol Chem. 2013 Mar 22;288(12):8619-26. doi: 10.1074/jbc.M112.445015

Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC
  • AuthorJungwook Kim, and Steven C. Almo
  • Year2013
  • SourceBMC Struct Biol. 2013 Apr 24;13:5. doi: 10.1186/1472-6807-13-5

The gate that governs sulfotransferase selectivity
  • AuthorIan Cook, Ting Wang, Steven C. Almo, Jungwook Kim, Charles N. Falany, and Thomas S. Leyh
  • Year2013
  • SourceBiochemistry. 2013 Jan 15;52(2):415-24. doi: 10.1021/bi301492j
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